The major mobilization on Saturday, dubbed the "2010 Heart Attack" began in the early hours of the morning, with around 300 activists gathering at Thornton Park under a heavy police presence to march through the streets of Vancouver in an attempt to disrupt "business as usual" on the opening day of competition of the 2010 Games.

The march departed from Thornton Park just after 9:00 am, with the goal of reaching the intersection of Denman and Georgia, where buses destined for the Whistler venues have to pass. Police on bicycles ringed the march as it snaked its way through the streets towards the upscale downtown, turning up Hastings Street and moving into the heart of the city, nearly abandoned streets giving way to larger crowds as it progressed.