In the 200th episode of South Park, broadcast in the US and UK last week, Muhammad appeared several times inside a bear suit. Figures from other religions were also depicted, including a drug-snorting Buddha.
Wednesday's 201st episode saw any spoken references to Muhammad bleeped out, while a prominent banner stating "censored" was used in the programme.
Speaking in an interview with the Boing Boing website before the 200th show aired, the South Park team defended the scenes.
"We'd be so hypocritical against our own message, our own thoughts, if we said, 'okay, well let's not make fun of them because they won't hurt us,'" said Parker.